Drug interactions
Amphotericin b deoxycholate + Atracurium
Severity: Moderate
Amphotericin b deoxycholate and Atracurium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B can cause hypokalemia and hypomagnesemia, which may prolong or intensify neuromuscular blockade from atracurium. This can delay recovery of spontaneous breathing after surgery or ventilation.
What this interaction means in plain words
Amphotericin b deoxycholate and Atracurium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amphotericin-induced electrolyte depletion (potassium, magnesium) enhances the effect of nondepolarizing neuromuscular blockers.
What to do
Check and correct potassium and magnesium before and during neuromuscular blockade. Monitor neuromuscular function with train-of-four and titrate atracurium accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Frequently asked questions
Can I take Amphotericin b deoxycholate with Atracurium?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Atracurium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause hypokalemia and hypomagnesemia, which may prolong or intensify neuromuscular blockade from atracurium. This can delay recovery of spontaneous breathing after surgery or ventilation.
How serious is the interaction between Amphotericin b deoxycholate and Atracurium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during neuromuscular blockade. Monitor neuromuscular function with train-of-four and titrate atracurium accordingly.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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