Drug interactions
Amphotericin b deoxycholate + Captopril
Severity: Moderate
Amphotericin b deoxycholate and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate is nephrotoxic and can cause electrolyte disturbances and infusion-related hypotension. Captopril reduces glomerular filtration pressure, so the combination may increase the risk of acute kidney injury, especially in volume-depleted patients.
What this interaction means in plain words
Amphotericin b deoxycholate and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal hemodynamic compromise (amphotericin afferent vasoconstriction and tubular toxicity with ACE inhibitor efferent dilation) plus additive hypotensive effects.
What to do
Monitor serum creatinine, potassium and blood pressure during co-therapy and ensure adequate hydration. Consider temporarily holding captopril if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Captopril?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate is nephrotoxic and can cause electrolyte disturbances and infusion-related hypotension. Captopril reduces glomerular filtration pressure, so the combination may increase the risk of acute kidney injury, especially in volume-depleted patients.
How serious is the interaction between Amphotericin b deoxycholate and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and blood pressure during co-therapy and ensure adequate hydration. Consider temporarily holding captopril if renal function worsens.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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