Drug interactions
Amphotericin b deoxycholate + Dichlorphenamide
Severity: Moderate
Amphotericin b deoxycholate and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conventional amphotericin B commonly causes hypokalemia and distal renal tubular acidosis, and dichlorphenamide adds renal potassium and bicarbonate loss. The combination can produce marked electrolyte disturbance and arrhythmia risk.
What this interaction means in plain words
Amphotericin b deoxycholate and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting and bicarbonate loss from tubular toxicity and carbonic anhydrase inhibition.
What to do
Monitor serum potassium, magnesium and bicarbonate frequently and supplement as required; consider stopping dichlorphenamide if severe acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Amphotericin b deoxycholate with Dichlorphenamide?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conventional amphotericin B commonly causes hypokalemia and distal renal tubular acidosis, and dichlorphenamide adds renal potassium and bicarbonate loss. The combination can produce marked electrolyte disturbance and arrhythmia risk.
How serious is the interaction between Amphotericin b deoxycholate and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and bicarbonate frequently and supplement as required; consider stopping dichlorphenamide if severe acidosis develops.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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