Drug interactions
Amphotericin b deoxycholate + Hydrocortisone
Severity: Moderate
Amphotericin b deoxycholate and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote potassium loss, so combined use can cause significant hypokalemia. Amphotericin also causes renal tubular damage and magnesium wasting, which worsens electrolyte disturbance and arrhythmia risk.
What this interaction means in plain words
Amphotericin b deoxycholate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from amphotericin tubular toxicity and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium regularly and replace as needed. Use the lowest effective steroid dose and review any other potassium-lowering drugs or QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Hydrocortisone?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote potassium loss, so combined use can cause significant hypokalemia. Amphotericin also causes renal tubular damage and magnesium wasting, which worsens electrolyte disturbance and arrhythmia risk.
How serious is the interaction between Amphotericin b deoxycholate and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace as needed. Use the lowest effective steroid dose and review any other potassium-lowering drugs or QT-prolonging agents.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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