Drug interactions
Amphotericin b deoxycholate + Tobramycin
Severity: Major
Amphotericin b deoxycholate and Tobramycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic and together increase the risk of acute kidney injury and electrolyte wasting. Reduced clearance can raise tobramycin exposure and ototoxicity risk.
What this interaction means in plain words
Amphotericin b deoxycholate and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from tubular injury and renal vasoconstriction.
What to do
Avoid if alternatives exist, such as a lipid amphotericin formulation. If needed, monitor creatinine, potassium, magnesium and tobramycin levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b deoxycholate and Tobramycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
- Bacitracin + Tobramycin Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Tobramycin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic and together increase the risk of acute kidney injury and electrolyte wasting. Reduced clearance can raise tobramycin exposure and ototoxicity risk.
How serious is the interaction between Amphotericin b deoxycholate and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist, such as a lipid amphotericin formulation. If needed, monitor creatinine, potassium, magnesium and tobramycin levels.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
