Drug interactions
Amphotericin b phospholipid complex + Captopril
Severity: Minor
Amphotericin b phospholipid complex and Captopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lipid-based amphotericin B is less nephrotoxic than the deoxycholate form, but renal impairment and infusion reactions with hypotension can still occur. Captopril may add to the risk of kidney function decline and low blood pressure.
What this interaction means in plain words
Amphotericin b phospholipid complex and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effects on renal hemodynamics and blood pressure; the interaction is largely theoretical.
What to do
Monitor serum creatinine and blood pressure periodically during therapy. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Amphotericin b phospholipid complex with Captopril?
MediHelp rates the interaction as minor. Amphotericin b phospholipid complex and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lipid-based amphotericin B is less nephrotoxic than the deoxycholate form, but renal impairment and infusion reactions with hypotension can still occur. Captopril may add to the risk of kidney function decline and low blood pressure.
How serious is the interaction between Amphotericin b phospholipid complex and Captopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and blood pressure periodically during therapy. No dose change is usually needed.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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