Drug interactions
Amphotericin b phospholipid complex + Tenofovir disoproxil
Severity: Moderate
Amphotericin b phospholipid complex and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidneys, and combined use may worsen renal function. Reduced renal function in turn increases tenofovir exposure and the risk of tubular toxicity.
What this interaction means in plain words
Amphotericin b phospholipid complex and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of tenofovir as kidney function declines.
What to do
Monitor serum creatinine, phosphate and electrolytes regularly during combined therapy. Consider an alternative to tenofovir disoproxil if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b phospholipid complex and Tenofovir disoproxil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Frequently asked questions
Can I take Amphotericin b phospholipid complex with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Amphotericin b phospholipid complex and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidneys, and combined use may worsen renal function. Reduced renal function in turn increases tenofovir exposure and the risk of tubular toxicity.
How serious is the interaction between Amphotericin b phospholipid complex and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and electrolytes regularly during combined therapy. Consider an alternative to tenofovir disoproxil if renal function deteriorates.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
