Drug interactions
Amyl nitrite + Tadalafil
Severity: Contraindicated
Amyl nitrite and Tadalafil: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amyl nitrite is a rapid, potent vasodilator, and tadalafil greatly enhances its hypotensive effect. Profound hypotension, collapse and cardiac ischemia can result, including with recreational inhaled nitrites.
What this interaction means in plain words
Amyl nitrite and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nitrite-derived nitric oxide raises cGMP and PDE5 inhibition prevents its degradation, causing excessive additive vasodilation.
What to do
Do not use together; allow at least 48 hours after the last tadalafil dose before any nitrate. Advise patients to avoid recreational nitrites entirely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amyl nitrite and Tadalafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tadalafil
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
- Nitroglycerin transdermal + Tadalafil Contraindicated
Frequently asked questions
Can I take Amyl nitrite with Tadalafil?
MediHelp rates the interaction as contraindicated. Amyl nitrite and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amyl nitrite is a rapid, potent vasodilator, and tadalafil greatly enhances its hypotensive effect. Profound hypotension, collapse and cardiac ischemia can result, including with recreational inhaled nitrites.
How serious is the interaction between Amyl nitrite and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow at least 48 hours after the last tadalafil dose before any nitrate. Advise patients to avoid recreational nitrites entirely.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Isosorbide dinitrate, Isosorbide mononitrate, Nitroglycerin po. The full list is on the Tadalafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
