Drug interactions
Anastrozole + Bazedoxifene / conjugated estrogens
Severity: Contraindicated
Anastrozole and Bazedoxifene / conjugated estrogens: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anastrozole lowers estrogen levels in postmenopausal women with hormone receptor-positive breast cancer, whereas conjugated estrogens supply estrogen. The therapy opposes the intended anti-estrogen effect and may reduce cancer control.
What this interaction means in plain words
Anastrozole and Bazedoxifene / conjugated estrogens are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Pharmacodynamic antagonism: exogenous estrogen counteracts aromatase inhibition.
What to do
Do not combine. Use non-hormonal options for vasomotor symptoms in patients on anastrozole.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Anastrozole and Bazedoxifene / conjugated estrogens, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Anastrozole
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Anastrozole + Conjugated estrogens Contraindicated
- Anastrozole + Estradiol Contraindicated
- Anastrozole + Estrogens conjugated synthetic Contraindicated
- Anastrozole + Estrogens esterified Contraindicated
- Anastrozole + Estropipate Contraindicated
Frequently asked questions
Can I take Anastrozole with Bazedoxifene / conjugated estrogens?
MediHelp rates the interaction as contraindicated. Anastrozole and Bazedoxifene / conjugated estrogens are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Anastrozole lowers estrogen levels in postmenopausal women with hormone receptor-positive breast cancer, whereas conjugated estrogens supply estrogen. The therapy opposes the intended anti-estrogen effect and may reduce cancer control.
How serious is the interaction between Anastrozole and Bazedoxifene / conjugated estrogens?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use non-hormonal options for vasomotor symptoms in patients on anastrozole.
What other medicines interact with Anastrozole?
MediHelp also lists interactions of Anastrozole with, for example, Bazedoxifene-conjugated estrogens, Conjugated estrogens, Estradiol. The full list is on the Anastrozole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
