Drug interactions
Anidulafungin + Saccharomyces boulardii
Severity: Moderate
Anidulafungin and Saccharomyces boulardii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anidulafungin is active against yeasts and may reduce the viability of S. boulardii, lessening the probiotic effect. Live yeast probiotics have also been associated with fungemia in critically ill or catheterized patients.
What this interaction means in plain words
Anidulafungin and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: antifungal activity against the live yeast probiotic.
What to do
Avoid the probiotic during systemic antifungal therapy, especially in critically ill patients or those with central lines. Resume only after antifungal treatment is completed if still needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anidulafungin
Frequently asked questions
Can I take Anidulafungin with Saccharomyces boulardii?
MediHelp rates the interaction as moderate. Anidulafungin and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anidulafungin is active against yeasts and may reduce the viability of S. boulardii, lessening the probiotic effect. Live yeast probiotics have also been associated with fungemia in critically ill or catheterized patients.
How serious is the interaction between Anidulafungin and Saccharomyces boulardii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the probiotic during systemic antifungal therapy, especially in critically ill patients or those with central lines. Resume only after antifungal treatment is completed if still needed.
What other medicines interact with Anidulafungin?
MediHelp also lists interactions of Anidulafungin with, for example, Voclosporin. The full list is on the Anidulafungin page.
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