Drug interactions
Anthrax vaccine + Methotrexate
Severity: Moderate
Anthrax vaccine and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anthrax vaccine is non-live, so methotrexate does not create an infection risk but may blunt the antibody response and reduce protection.
What this interaction means in plain words
Anthrax vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate suppresses lymphocyte proliferation and antibody production after vaccination.
What to do
Vaccination is not contraindicated; if exposure risk is significant, give the vaccine regardless and consider checking response or timing doses when immunosuppression is lowest.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Anthrax vaccine with Methotrexate?
MediHelp rates the interaction as moderate. Anthrax vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anthrax vaccine is non-live, so methotrexate does not create an infection risk but may blunt the antibody response and reduce protection.
How serious is the interaction between Anthrax vaccine and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination is not contraindicated; if exposure risk is significant, give the vaccine regardless and consider checking response or timing doses when immunosuppression is lowest.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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