Drug interactions
Antipyrine + Peginterferon alfa 2a
Severity: Minor
Antipyrine and Peginterferon alfa 2a: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2a can inhibit CYP1A2 and reduce clearance of probe substrates such as theophylline. Antipyrine is mainly used as a research metabolic probe, so any effect has little clinical relevance.
What this interaction means in plain words
Antipyrine and Peginterferon alfa 2a have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Interferon-mediated reduction of hepatic CYP activity, including CYP1A2, decreasing antipyrine clearance.
What to do
No action needed clinically; interpret antipyrine clearance results cautiously during interferon therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2a
Frequently asked questions
Can I take Antipyrine with Peginterferon alfa 2a?
MediHelp rates the interaction as minor. Antipyrine and Peginterferon alfa 2a have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2a can inhibit CYP1A2 and reduce clearance of probe substrates such as theophylline. Antipyrine is mainly used as a research metabolic probe, so any effect has little clinical relevance.
How serious is the interaction between Antipyrine and Peginterferon alfa 2a?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed clinically; interpret antipyrine clearance results cautiously during interferon therapy.
What other medicines interact with Peginterferon alfa 2a?
MediHelp also lists interactions of Peginterferon alfa 2a with, for example, Clozapine, Deferiprone, Hydroxycarbamide. The full list is on the Peginterferon alfa 2a page.
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