Drug interactions
Antithrombin alfa + Budesonide
Severity: Minor
Antithrombin alfa and Budesonide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids have inconsistent effects on hemostasis and may alter clotting or affect vascular and mucosal integrity. Combined with a recombinant antithrombin that potentiates anticoagulation, this could in theory increase bleeding risk. Clinical significance with budesonide, especially inhaled or locally acting forms, is likely small.
What this interaction means in plain words
Antithrombin alfa and Budesonide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive pharmacodynamic effects on hemostasis and mucosal integrity; the mechanism is not well established.
What to do
Monitor for signs of bleeding and follow antithrombin activity and coagulation parameters as already required for antithrombin therapy. No dose change is needed routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Frequently asked questions
Can I take Antithrombin alfa with Budesonide?
MediHelp rates the interaction as minor. Antithrombin alfa and Budesonide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids have inconsistent effects on hemostasis and may alter clotting or affect vascular and mucosal integrity. Combined with a recombinant antithrombin that potentiates anticoagulation, this could in theory increase bleeding risk. Clinical significance with budesonide, especially inhaled or locally acting forms, is likely small.
How serious is the interaction between Antithrombin alfa and Budesonide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and follow antithrombin activity and coagulation parameters as already required for antithrombin therapy. No dose change is needed routinely.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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