Drug interactions
Antithrombin alfa + Fenoprofen
Severity: Moderate
Antithrombin alfa and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin alfa enhances heparin-mediated anticoagulation, while fenoprofen impairs platelet function and can injure the GI mucosa. Together they increase bleeding risk.
What this interaction means in plain words
Antithrombin alfa and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: antithrombin potentiates thrombin and factor Xa inhibition while NSAIDs inhibit platelet COX-1.
What to do
Monitor for bleeding signs and hemoglobin, and avoid the NSAID where an alternative analgesic such as paracetamol is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Antithrombin alfa with Fenoprofen?
MediHelp rates the interaction as moderate. Antithrombin alfa and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin alfa enhances heparin-mediated anticoagulation, while fenoprofen impairs platelet function and can injure the GI mucosa. Together they increase bleeding risk.
How serious is the interaction between Antithrombin alfa and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and hemoglobin, and avoid the NSAID where an alternative analgesic such as paracetamol is suitable.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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