Drug interactions
Antithrombin alfa + Ketorolac
Severity: Major
Antithrombin alfa and Ketorolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin-type anticoagulation, and ketorolac impairs platelet function and damages GI mucosa. Together they raise the risk of significant bleeding. Ketorolac is itself labeled as contraindicated in patients at high bleeding risk.
What this interaction means in plain words
Antithrombin alfa and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment from anticoagulant effect plus NSAID-induced platelet inhibition.
What to do
Avoid ketorolac in patients receiving antithrombin therapy where possible; if unavoidable, monitor for bleeding and coagulation parameters.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Antithrombin alfa with Ketorolac?
MediHelp rates the interaction as major. Antithrombin alfa and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antithrombin potentiates heparin-type anticoagulation, and ketorolac impairs platelet function and damages GI mucosa. Together they raise the risk of significant bleeding. Ketorolac is itself labeled as contraindicated in patients at high bleeding risk.
How serious is the interaction between Antithrombin alfa and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients receiving antithrombin therapy where possible; if unavoidable, monitor for bleeding and coagulation parameters.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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