Drug interactions
Antithrombin alfa + Tirofiban
Severity: Major
Antithrombin alfa and Tirofiban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together they impair hemostasis through distinct pathways and increase the risk of serious bleeding.
What this interaction means in plain words
Antithrombin alfa and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effect of GP IIb/IIIa platelet inhibition and antithrombin-mediated anticoagulation.
What to do
Avoid unless clearly indicated; if used, monitor anti-Xa or aPTT, platelets, hemoglobin and bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tirofiban
Frequently asked questions
Can I take Antithrombin alfa with Tirofiban?
MediHelp rates the interaction as major. Antithrombin alfa and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Together they impair hemostasis through distinct pathways and increase the risk of serious bleeding.
How serious is the interaction between Antithrombin alfa and Tirofiban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly indicated; if used, monitor anti-Xa or aPTT, platelets, hemoglobin and bleeding.
What other medicines interact with Tirofiban?
MediHelp also lists interactions of Tirofiban with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Tirofiban page.
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