Drug interactions
Antithrombin iii + Citalopram
Severity: Moderate
Antithrombin iii and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances anticoagulation, while citalopram impairs platelet function through serotonin depletion. Together they may increase bleeding risk.
What this interaction means in plain words
Antithrombin iii and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis: anticoagulant potentiation plus SSRI-related platelet dysfunction.
What to do
Monitor for bleeding and coagulation parameters during antithrombin therapy. Reassess need for citalopram in patients at high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Antithrombin iii with Citalopram?
MediHelp rates the interaction as moderate. Antithrombin iii and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances anticoagulation, while citalopram impairs platelet function through serotonin depletion. Together they may increase bleeding risk.
How serious is the interaction between Antithrombin iii and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters during antithrombin therapy. Reassess need for citalopram in patients at high bleeding risk.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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