Drug interactions
Antithrombin iii + Eptifibatide
Severity: Major
Antithrombin iii and Eptifibatide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III potentiates anticoagulation while eptifibatide blocks platelet aggregation, so serious bleeding risk is increased.
What this interaction means in plain words
Antithrombin iii and Eptifibatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effect of GP IIb/IIIa blockade and enhanced thrombin and factor Xa inhibition.
What to do
Avoid unless clearly indicated; if used, monitor coagulation tests, platelets and bleeding signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eptifibatide
Frequently asked questions
Can I take Antithrombin iii with Eptifibatide?
MediHelp rates the interaction as major. Antithrombin iii and Eptifibatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antithrombin III potentiates anticoagulation while eptifibatide blocks platelet aggregation, so serious bleeding risk is increased.
How serious is the interaction between Antithrombin iii and Eptifibatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly indicated; if used, monitor coagulation tests, platelets and bleeding signs.
What other medicines interact with Eptifibatide?
MediHelp also lists interactions of Eptifibatide with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Eptifibatide page.
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