Drug interactions
Antithrombin iii + Fenoprofen
Severity: Moderate
Antithrombin iii and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen inhibits platelet function and can irritate the gastric mucosa, while antithrombin III enhances inhibition of clotting factors. Taken together, the risk of bleeding, especially gastrointestinal, is increased.
What this interaction means in plain words
Antithrombin iii and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: NSAID-induced platelet inhibition and mucosal injury combined with potentiated anticoagulation.
What to do
Monitor for signs of bleeding and coagulation parameters, and use the lowest effective NSAID dose for the shortest time. Consider acetaminophen as an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Antithrombin iii with Fenoprofen?
MediHelp rates the interaction as moderate. Antithrombin iii and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen inhibits platelet function and can irritate the gastric mucosa, while antithrombin III enhances inhibition of clotting factors. Taken together, the risk of bleeding, especially gastrointestinal, is increased.
How serious is the interaction between Antithrombin iii and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and coagulation parameters, and use the lowest effective NSAID dose for the shortest time. Consider acetaminophen as an alternative analgesic.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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