Drug interactions
Antithrombin iii + Fluorouracil
Severity: Moderate
Antithrombin iii and Fluorouracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil can cause thrombocytopenia, and antithrombin III enhances heparin anticoagulation. In combination the bleeding risk may be higher.
What this interaction means in plain words
Antithrombin iii and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia plus anticoagulant effect.
What to do
Monitor platelet counts and coagulation parameters, and watch for bleeding; adjust the anticoagulant for low platelets.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Antithrombin iii and Fluorouracil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluorouracil
Frequently asked questions
Can I take Antithrombin iii with Fluorouracil?
MediHelp rates the interaction as moderate. Antithrombin iii and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluorouracil can cause thrombocytopenia, and antithrombin III enhances heparin anticoagulation. In combination the bleeding risk may be higher.
How serious is the interaction between Antithrombin iii and Fluorouracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and coagulation parameters, and watch for bleeding; adjust the anticoagulant for low platelets.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
