Drug interactions
Aprotinin + Captopril
Severity: Moderate
Aprotinin and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprotinin inhibits the kallikrein-kinin system and may blunt the blood pressure lowering effect of ACE inhibitors, which partly depend on bradykinin. Reported effects are mainly in the perioperative setting.
What this interaction means in plain words
Aprotinin and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Kallikrein inhibition by aprotinin reduces bradykinin-mediated vasodilation contributing to ACE inhibitor effect.
What to do
Monitor blood pressure around aprotinin administration and adjust antihypertensive therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Aprotinin with Captopril?
MediHelp rates the interaction as moderate. Aprotinin and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprotinin inhibits the kallikrein-kinin system and may blunt the blood pressure lowering effect of ACE inhibitors, which partly depend on bradykinin. Reported effects are mainly in the perioperative setting.
How serious is the interaction between Aprotinin and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure around aprotinin administration and adjust antihypertensive therapy as required.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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