Drug interactions
Arformoterol + Dichlorphenamide
Severity: Moderate
Arformoterol and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol, a long-acting beta-2 agonist, can lower serum potassium by driving it into cells, and dichlorphenamide increases renal potassium loss. Combined hypokalemia may raise the risk of arrhythmias, especially in patients with heart disease.
What this interaction means in plain words
Arformoterol and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive hypokalemia from beta-2 stimulated cellular potassium uptake and renal potassium wasting.
What to do
Monitor serum potassium at baseline and periodically, and correct hypokalemia, particularly in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Dichlorphenamide?
MediHelp rates the interaction as moderate. Arformoterol and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol, a long-acting beta-2 agonist, can lower serum potassium by driving it into cells, and dichlorphenamide increases renal potassium loss. Combined hypokalemia may raise the risk of arrhythmias, especially in patients with heart disease.
How serious is the interaction between Arformoterol and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium at baseline and periodically, and correct hypokalemia, particularly in patients with cardiac risk factors.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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