Drug interactions
Arformoterol + Donepezil
Severity: Moderate
Arformoterol and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval, and arformoterol can cause tachycardia, hypokalemia and QT prolongation. Combined use may increase arrhythmia risk, particularly in patients with heart disease.
What this interaction means in plain words
Arformoterol and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-agonist induced hypokalemia.
What to do
Monitor heart rhythm and potassium in patients with cardiac disease or other QT risk factors. Avoid exceeding the recommended arformoterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Arformoterol and Donepezil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Donepezil?
MediHelp rates the interaction as moderate. Arformoterol and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can prolong the QT interval, and arformoterol can cause tachycardia, hypokalemia and QT prolongation. Combined use may increase arrhythmia risk, particularly in patients with heart disease.
How serious is the interaction between Arformoterol and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and potassium in patients with cardiac disease or other QT risk factors. Avoid exceeding the recommended arformoterol dose.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
