Drug interactions
Arformoterol + Epinephrine
Severity: Moderate
Arformoterol and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol is a long-acting beta2-agonist, and adding epinephrine can cause additive cardiovascular stimulation including tachycardia, hypertension and arrhythmias. Both can also lower serum potassium, which may increase arrhythmia risk.
What this interaction means in plain words
Arformoterol and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Epinephrine belongs to Endocrine.
Why it happens
Additive beta-adrenergic receptor stimulation with intracellular potassium shift.
What to do
Monitor heart rate, blood pressure and serum potassium, especially with systemic epinephrine or cardiac disease. Use caution with repeated or high doses of epinephrine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Epinephrine?
MediHelp rates the interaction as moderate. Arformoterol and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol is a long-acting beta2-agonist, and adding epinephrine can cause additive cardiovascular stimulation including tachycardia, hypertension and arrhythmias. Both can also lower serum potassium, which may increase arrhythmia risk.
How serious is the interaction between Arformoterol and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and serum potassium, especially with systemic epinephrine or cardiac disease. Use caution with repeated or high doses of epinephrine.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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