Drug interactions
Arformoterol + Phenylephrine
Severity: Moderate
Arformoterol and Phenylephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sympathomimetics. Together they may additively raise heart rate and blood pressure and increase the risk of palpitations or arrhythmias, particularly in patients with cardiovascular disease.
What this interaction means in plain words
Arformoterol and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Phenylephrine belongs to Respiratory.
Why it happens
Additive adrenergic stimulation from alpha-1 agonism (phenylephrine) and beta-2 agonism (arformoterol).
What to do
Monitor blood pressure, heart rate and rhythm, especially with systemic phenylephrine. Avoid oral decongestants in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Phenylephrine?
MediHelp rates the interaction as moderate. Arformoterol and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sympathomimetics. Together they may additively raise heart rate and blood pressure and increase the risk of palpitations or arrhythmias, particularly in patients with cardiovascular disease.
How serious is the interaction between Arformoterol and Phenylephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and rhythm, especially with systemic phenylephrine. Avoid oral decongestants in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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