Drug interactions
Arformoterol + Propranolol
Severity: Major
Arformoterol and Propranolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol antagonizes the bronchodilating effect of arformoterol and may provoke bronchospasm in patients with airway disease. The therapeutic effect of the long-acting beta agonist may be lost.
What this interaction means in plain words
Arformoterol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arformoterol belongs to Respiratory; Propranolol belongs to Cardiovascular.
Why it happens
Non-selective beta-2 receptor blockade by propranolol competitively antagonizes arformoterol.
What to do
Avoid the combination; if a beta-blocker is required, choose a cardioselective agent and monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Propranolol?
MediHelp rates the interaction as major. Arformoterol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol antagonizes the bronchodilating effect of arformoterol and may provoke bronchospasm in patients with airway disease. The therapeutic effect of the long-acting beta agonist may be lost.
How serious is the interaction between Arformoterol and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a beta-blocker is required, choose a cardioselective agent and monitor respiratory function.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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