Drug interactions
Artemether / lumefantrine + Budesonide
Severity: Minor
Artemether / lumefantrine and Budesonide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has weak CYP3A4 induction potential and lumefantrine is a CYP3A4 substrate, so exposure to budesonide could fall slightly. Conversely budesonide is not a recognized relevant inhibitor or inducer affecting the antimalarial. The effect is expected to be small and short-lived with a standard three-day course.
What this interaction means in plain words
Artemether / lumefantrine and Budesonide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by artemether reducing budesonide metabolism-dependent exposure.
What to do
No routine adjustment is needed for a short antimalarial course. Watch for reduced budesonide effect if used for a serious condition such as Crohn's disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Frequently asked questions
Can I take Artemether / lumefantrine with Budesonide?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Budesonide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether has weak CYP3A4 induction potential and lumefantrine is a CYP3A4 substrate, so exposure to budesonide could fall slightly. Conversely budesonide is not a recognized relevant inhibitor or inducer affecting the antimalarial. The effect is expected to be small and short-lived with a standard three-day course.
How serious is the interaction between Artemether / lumefantrine and Budesonide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for a short antimalarial course. Watch for reduced budesonide effect if used for a serious condition such as Crohn's disease.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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