Drug interactions
Artemether / lumefantrine + Darifenacin
Severity: Moderate
Artemether / lumefantrine and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether and lumefantrine are CYP3A4 substrates and lumefantrine inhibits CYP2D6, an enzyme contributing to darifenacin metabolism. Darifenacin concentrations may rise, increasing anticholinergic effects, and artemether may induce CYP3A4 with a modest effect in the opposite direction.
What this interaction means in plain words
Artemether / lumefantrine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumefantrine inhibits CYP2D6 while artemether can weakly induce CYP3A4, altering darifenacin metabolism in an unpredictable direction.
What to do
Monitor for anticholinergic adverse effects or reduced bladder symptom control during the short antimalarial course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Artemether / lumefantrine with Darifenacin?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether and lumefantrine are CYP3A4 substrates and lumefantrine inhibits CYP2D6, an enzyme contributing to darifenacin metabolism. Darifenacin concentrations may rise, increasing anticholinergic effects, and artemether may induce CYP3A4 with a modest effect in the opposite direction.
How serious is the interaction between Artemether / lumefantrine and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects or reduced bladder symptom control during the short antimalarial course.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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