Drug interactions
Artemether / lumefantrine + Dextroamphetamine
Severity: Moderate
Artemether / lumefantrine and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6, one of the enzymes involved in amphetamine metabolism, so dextroamphetamine exposure may increase. This could enhance stimulant effects such as tachycardia, hypertension and anxiety. The effect is likely modest during a short antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated metabolism of dextroamphetamine.
What to do
Monitor for increased stimulant effects, including heart rate and blood pressure, during the antimalarial course. Reduce the dextroamphetamine dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Dextroamphetamine?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6, one of the enzymes involved in amphetamine metabolism, so dextroamphetamine exposure may increase. This could enhance stimulant effects such as tachycardia, hypertension and anxiety. The effect is likely modest during a short antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased stimulant effects, including heart rate and blood pressure, during the antimalarial course. Reduce the dextroamphetamine dose if symptoms occur.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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