Drug interactions
Artemether / lumefantrine + Etoposide
Severity: Minor
Artemether / lumefantrine and Etoposide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has weak CYP3A4 inducing potential, which could modestly increase the metabolism of etoposide and lower its exposure. The clinical relevance is uncertain, and antimalarial courses are short.
What this interaction means in plain words
Artemether / lumefantrine and Etoposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by artemether increases etoposide metabolism.
What to do
No routine dose change is needed; monitor response to etoposide if the antimalarial is used for a prolonged course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Artemether / lumefantrine with Etoposide?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Etoposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether has weak CYP3A4 inducing potential, which could modestly increase the metabolism of etoposide and lower its exposure. The clinical relevance is uncertain, and antimalarial courses are short.
How serious is the interaction between Artemether / lumefantrine and Etoposide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor response to etoposide if the antimalarial is used for a prolonged course.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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