Drug interactions
Artemether / lumefantrine + Griseofulvin
Severity: Moderate
Artemether / lumefantrine and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak to moderate CYP3A4 inducer and may lower artemether and lumefantrine concentrations. Reduced exposure could lead to treatment failure or recrudescence of malaria.
What this interaction means in plain words
Artemether / lumefantrine and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by griseofulvin increases metabolism of artemether and lumefantrine.
What to do
Avoid the combination if possible; if used, monitor closely for clinical and parasitological response and consider alternative antimalarial therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Artemether / lumefantrine with Griseofulvin?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin is a weak to moderate CYP3A4 inducer and may lower artemether and lumefantrine concentrations. Reduced exposure could lead to treatment failure or recrudescence of malaria.
How serious is the interaction between Artemether / lumefantrine and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor closely for clinical and parasitological response and consider alternative antimalarial therapy.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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