Drug interactions
Artemether / lumefantrine + Isoniazid
Severity: Minor
Artemether / lumefantrine and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may weakly inhibit CYP3A4, potentially raising artemether and lumefantrine exposure. Lumefantrine can prolong QT, so a rise is of theoretical concern, though the effect of isoniazid is probably small.
What this interaction means in plain words
Artemether / lumefantrine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by isoniazid may reduce metabolism of artemether and lumefantrine.
What to do
No routine adjustment needed. Consider ECG monitoring if other QT-prolonging drugs or risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Artemether / lumefantrine with Isoniazid?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may weakly inhibit CYP3A4, potentially raising artemether and lumefantrine exposure. Lumefantrine can prolong QT, so a rise is of theoretical concern, though the effect of isoniazid is probably small.
How serious is the interaction between Artemether / lumefantrine and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed. Consider ECG monitoring if other QT-prolonging drugs or risk factors are present.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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