Drug interactions
Artemether / lumefantrine + Sorafenib
Severity: Major
Artemether / lumefantrine and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval, and sorafenib may add to this effect. The combination may raise the risk of ventricular arrhythmia.
What this interaction means in plain words
Artemether / lumefantrine and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if possible, or consider an alternative antimalarial. If used, obtain an ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sorafenib
- Adagrasib + Sorafenib Major
- Amiodarone + Sorafenib Major
- Amisulpride + Sorafenib Major
- Anagrelide + Sorafenib Major
- Arsenic trioxide + Sorafenib Major
- Artemether + Sorafenib Major
Frequently asked questions
Can I take Artemether / lumefantrine with Sorafenib?
MediHelp rates the interaction as major. Artemether / lumefantrine and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine can prolong the QT interval, and sorafenib may add to this effect. The combination may raise the risk of ventricular arrhythmia.
How serious is the interaction between Artemether / lumefantrine and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or consider an alternative antimalarial. If used, obtain an ECG and correct electrolytes.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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