Drug interactions
Artemether / lumefantrine + Topiramate
Severity: Moderate
Artemether / lumefantrine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak to moderate CYP3A4 inducer and may lower exposure to artemether and lumefantrine. Reduced antimalarial exposure could lessen efficacy and raise the risk of treatment failure.
What this interaction means in plain words
Artemether / lumefantrine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by topiramate increases metabolism of artemether and lumefantrine.
What to do
Monitor for clinical response and recrudescence, and ensure full-course dosing with food. Consider an alternative antimalarial if treatment failure is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Frequently asked questions
Can I take Artemether / lumefantrine with Topiramate?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate is a weak to moderate CYP3A4 inducer and may lower exposure to artemether and lumefantrine. Reduced antimalarial exposure could lessen efficacy and raise the risk of treatment failure.
How serious is the interaction between Artemether / lumefantrine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical response and recrudescence, and ensure full-course dosing with food. Consider an alternative antimalarial if treatment failure is a concern.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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