Drug interactions
Asenapine transdermal + Fentanyl
Severity: Moderate
Asenapine transdermal and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a sedating antipsychotic and adds to opioid-related sedation, hypotension and respiratory depression. The risk is greater with higher doses and in frail patients.
What this interaction means in plain words
Asenapine transdermal and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic antagonism of histamine, adrenergic and other receptors.
What to do
Monitor for sedation, orthostatic hypotension and respiratory depression, and reduce the dose of either drug if excessive sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Asenapine transdermal with Fentanyl?
MediHelp rates the interaction as moderate. Asenapine transdermal and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is a sedating antipsychotic and adds to opioid-related sedation, hypotension and respiratory depression. The risk is greater with higher doses and in frail patients.
How serious is the interaction between Asenapine transdermal and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and respiratory depression, and reduce the dose of either drug if excessive sedation develops.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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