Drug interactions
Asenapine transdermal + Pimozide
Severity: Contraindicated
Asenapine transdermal and Pimozide: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is an antipsychotic with QT-prolonging potential, and pimozide strongly prolongs QT. Using both increases the risk of serious ventricular arrhythmias, and the transdermal route provides systemic exposure.
What this interaction means in plain words
Asenapine transdermal and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive hERG channel blockade causing QT prolongation.
What to do
Avoid combining the two antipsychotics. Use one agent, and check ECG and electrolytes when switching.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Pimozide?
MediHelp rates the interaction as contraindicated. Asenapine transdermal and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Asenapine is an antipsychotic with QT-prolonging potential, and pimozide strongly prolongs QT. Using both increases the risk of serious ventricular arrhythmias, and the transdermal route provides systemic exposure.
How serious is the interaction between Asenapine transdermal and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two antipsychotics. Use one agent, and check ECG and electrolytes when switching.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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