Drug interactions
Acetylsalicylic acid + Candesartan
Severity: Moderate
Acetylsalicylic acid and Candesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic doses of aspirin can blunt the antihypertensive effect of candesartan and increase the risk of acute kidney injury, especially in older or volume-depleted patients. Hyperkalemia risk may also rise.
What this interaction means in plain words
Acetylsalicylic acid and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Candesartan belongs to Cardiovascular.
Why it happens
Inhibition of renal vasodilatory prostaglandins reduces renal perfusion and antagonizes ARB effect.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium. Low-dose aspirin usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Acetylsalicylic acid with Candesartan?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic doses of aspirin can blunt the antihypertensive effect of candesartan and increase the risk of acute kidney injury, especially in older or volume-depleted patients. Hyperkalemia risk may also rise.
How serious is the interaction between Acetylsalicylic acid and Candesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium. Low-dose aspirin usually needs no change.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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