Drug interactions
Acetylsalicylic acid + Chlorpropamide
Severity: Moderate
Acetylsalicylic acid and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide and lead to hypoglycemia. The effect is most relevant with regular analgesic or anti-inflammatory aspirin doses rather than low-dose antiplatelet use.
What this interaction means in plain words
Acetylsalicylic acid and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Chlorpropamide belongs to Endocrine.
Why it happens
Salicylates displace sulfonylureas from plasma protein binding, may reduce their renal elimination, and have intrinsic glucose-lowering effects.
What to do
Monitor blood glucose when starting or stopping regular-dose aspirin and educate the patient on hypoglycemia symptoms. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Acetylsalicylic acid with Chlorpropamide?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates can enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide and lead to hypoglycemia. The effect is most relevant with regular analgesic or anti-inflammatory aspirin doses rather than low-dose antiplatelet use.
How serious is the interaction between Acetylsalicylic acid and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping regular-dose aspirin and educate the patient on hypoglycemia symptoms. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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