Drug interactions
Chlorpropamide + Insulin degludec-insulin aspart
Severity: Major
Chlorpropamide and Insulin degludec-insulin aspart: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with a sulfonylurea gives additive glucose lowering and raises the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged, especially in older adults and in renal impairment.
What this interaction means in plain words
Chlorpropamide and Insulin degludec-insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpropamide belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Additive effect: chlorpropamide stimulates insulin secretion while exogenous insulin directly lowers glucose.
What to do
Reduce the insulin or sulfonylurea dose when combining and monitor blood glucose closely. Consider a shorter-acting agent instead of chlorpropamide, particularly in elderly or renally impaired patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-insulin aspart
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Insulin degludec-insulin aspart?
MediHelp rates the interaction as major. Chlorpropamide and Insulin degludec-insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining insulin with a sulfonylurea gives additive glucose lowering and raises the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged, especially in older adults and in renal impairment.
How serious is the interaction between Chlorpropamide and Insulin degludec-insulin aspart?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the insulin or sulfonylurea dose when combining and monitor blood glucose closely. Consider a shorter-acting agent instead of chlorpropamide, particularly in elderly or renally impaired patients.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Clozapine, Diazoxide, Ethanol. The full list is on the Insulin degludec-insulin aspart page.
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