Drug interactions
Acetylsalicylic acid + Chlorthalidone
Severity: Moderate
Acetylsalicylic acid and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin at anti-inflammatory doses can reduce the diuretic and antihypertensive effect of chlorthalidone and may impair renal function, particularly in volume-depleted or elderly patients. Low-dose aspirin rarely causes a meaningful effect.
What this interaction means in plain words
Acetylsalicylic acid and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Chlorthalidone belongs to Cardiovascular.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing the diuretic effect.
What to do
Monitor blood pressure, fluid status and renal function when higher-dose aspirin is used with chlorthalidone. Ensure adequate hydration and adjust the diuretic dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Acetylsalicylic acid with Chlorthalidone?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin at anti-inflammatory doses can reduce the diuretic and antihypertensive effect of chlorthalidone and may impair renal function, particularly in volume-depleted or elderly patients. Low-dose aspirin rarely causes a meaningful effect.
How serious is the interaction between Acetylsalicylic acid and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function when higher-dose aspirin is used with chlorthalidone. Ensure adequate hydration and adjust the diuretic dose if control worsens.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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