Drug interactions
Acetylsalicylic acid + Cyanocobalamin
Severity: Minor
Acetylsalicylic acid and Cyanocobalamin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term high-dose aspirin may reduce oral vitamin B12 absorption through effects on the gastric mucosa. Clinically important deficiency is uncommon with usual aspirin doses.
What this interaction means in plain words
Acetylsalicylic acid and Cyanocobalamin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Cyanocobalamin belongs to Miscellaneous.
Why it happens
Aspirin-related gastric mucosal changes may impair absorption of oral vitamin B12.
What to do
No routine action is needed. Consider checking B12 status in patients on prolonged high-dose aspirin with other risk factors for deficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Acetylsalicylic acid with Cyanocobalamin?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Cyanocobalamin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term high-dose aspirin may reduce oral vitamin B12 absorption through effects on the gastric mucosa. Clinically important deficiency is uncommon with usual aspirin doses.
How serious is the interaction between Acetylsalicylic acid and Cyanocobalamin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Consider checking B12 status in patients on prolonged high-dose aspirin with other risk factors for deficiency.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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