Drug interactions
Cyanocobalamin + Neomycin po
Severity: Moderate
Cyanocobalamin and Neomycin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin can reduce absorption of oral vitamin B12 and with prolonged use may contribute to B12 deficiency. The effect is more relevant with long-term or high-dose neomycin.
What this interaction means in plain words
Cyanocobalamin and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Neomycin damages intestinal mucosa and may bind bile acids and precipitate, impairing B12 uptake in the ileum.
What to do
Monitor B12 status during prolonged neomycin therapy and use parenteral B12 if deficiency develops or oral absorption is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Neomycin po?
MediHelp rates the interaction as moderate. Cyanocobalamin and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin can reduce absorption of oral vitamin B12 and with prolonged use may contribute to B12 deficiency. The effect is more relevant with long-term or high-dose neomycin.
How serious is the interaction between Cyanocobalamin and Neomycin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor B12 status during prolonged neomycin therapy and use parenteral B12 if deficiency develops or oral absorption is a concern.
What other medicines interact with Cyanocobalamin?
MediHelp also lists interactions of Cyanocobalamin with, for example, Chloramphenicol, Acetylsalicylic acid, Alogliptin-metformin. The full list is on the Cyanocobalamin page.
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