Drug interactions
Acetylsalicylic acid + Dipyridamole
Severity: Moderate
Acetylsalicylic acid and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole combined with aspirin gives additive antiplatelet effects and a higher bleeding tendency. The combination is used deliberately for secondary stroke prevention.
What this interaction means in plain words
Acetylsalicylic acid and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Dipyridamole belongs to Cardiovascular.
Why it happens
Complementary antiplatelet actions: COX-1 inhibition by aspirin and adenosine reuptake and phosphodiesterase inhibition by dipyridamole.
What to do
Use when indicated and monitor for bleeding signs, particularly GI bleeding. Review the need for therapy if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Acetylsalicylic acid with Dipyridamole?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole combined with aspirin gives additive antiplatelet effects and a higher bleeding tendency. The combination is used deliberately for secondary stroke prevention.
How serious is the interaction between Acetylsalicylic acid and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use when indicated and monitor for bleeding signs, particularly GI bleeding. Review the need for therapy if bleeding occurs.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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