Drug interactions
Betrixaban + Dipyridamole
Severity: Major
Betrixaban and Dipyridamole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole inhibits P-glycoprotein and may increase betrixaban exposure. Together with the additive antiplatelet and anticoagulant effects, bleeding risk rises.
What this interaction means in plain words
Betrixaban and Dipyridamole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
P-glycoprotein inhibition by dipyridamole increases betrixaban levels, plus additive effects on hemostasis.
What to do
Reduce betrixaban to the labeled P-gp inhibitor dose of 80 mg once then 40 mg daily. Monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
- Dipyridamole + Vorapaxar Major
Frequently asked questions
Can I take Betrixaban with Dipyridamole?
MediHelp rates the interaction as major. Betrixaban and Dipyridamole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipyridamole inhibits P-glycoprotein and may increase betrixaban exposure. Together with the additive antiplatelet and anticoagulant effects, bleeding risk rises.
How serious is the interaction between Betrixaban and Dipyridamole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to the labeled P-gp inhibitor dose of 80 mg once then 40 mg daily. Monitor for bleeding.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Dabigatran. The full list is on the Dipyridamole page.
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