Drug interactions
Acetylsalicylic acid + Drospirenone
Severity: Minor
Acetylsalicylic acid and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. Low-dose aspirin is unlikely to add much, but high-dose regular aspirin may contribute to hyperkalemia through renal prostaglandin inhibition.
What this interaction means in plain words
Acetylsalicylic acid and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Drospirenone belongs to Endocrine.
Why it happens
Drospirenone's antialdosterone effect combined with aspirin-related prostaglandin inhibition may reduce renal potassium excretion.
What to do
Check serum potassium during the first cycle in patients taking regular high-dose aspirin or NSAIDs with drospirenone, especially those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Acetylsalicylic acid with Drospirenone?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has antimineralocorticoid activity and can raise serum potassium. Low-dose aspirin is unlikely to add much, but high-dose regular aspirin may contribute to hyperkalemia through renal prostaglandin inhibition.
How serious is the interaction between Acetylsalicylic acid and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle in patients taking regular high-dose aspirin or NSAIDs with drospirenone, especially those with renal impairment.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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