Drug reference
drospirenone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Progestin Preparations)
Mechanism of action
Spironolactone analogue with antimineralocorticoid and antiandrogenic activity; suppresses luteinizing hormone and ovulation by binding to the progesterone receptor; also alters cervical mucus, causing unfavorable sperm penetration; changes to the endometrial lining may decrease implantation
Common side effects
- Headache
- Acne
- Unscheduled bleeding
- Metrorrhagia
- Breast pain
- Weight increased
Known interactions (4)
- drospirenone + eplerenone Major
- amiloride + drospirenone Moderate
- drospirenone + spironolactone Moderate
- drospirenone + triamterene Moderate
Related conditions
Frequently asked questions
What drug class is drospirenone?
drospirenone belongs to: Endocrine.
How does drospirenone work?
Spironolactone analogue with antimineralocorticoid and antiandrogenic activity; suppresses luteinizing hormone and ovulation by binding to the progesterone receptor; also alters cervical mucus, causing unfavorable sperm penetration; changes to the endometrial lining may decrease implantation
What are the common side effects of drospirenone?
Headache, Acne, Unscheduled bleeding, Metrorrhagia, Breast pain, Weight increased
Which drugs interact with drospirenone?
eplerenone, amiloride, spironolactone, triamterene
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