Drug interactions
Acetylsalicylic acid + Eprosartan
Severity: Moderate
Acetylsalicylic acid and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAID-dose aspirin can blunt the antihypertensive effect of eprosartan and, in volume-depleted or elderly patients, contribute to acute kidney injury and hyperkalemia. Low-dose aspirin carries much less risk.
What this interaction means in plain words
Acetylsalicylic acid and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Eprosartan belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion, which is critical when angiotensin II receptor action is blocked.
What to do
Monitor blood pressure, serum creatinine and potassium when regular analgesic-dose aspirin is given with eprosartan, and maintain hydration. Prefer low-dose aspirin or alternative analgesics where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Acetylsalicylic acid with Eprosartan?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAID-dose aspirin can blunt the antihypertensive effect of eprosartan and, in volume-depleted or elderly patients, contribute to acute kidney injury and hyperkalemia. Low-dose aspirin carries much less risk.
How serious is the interaction between Acetylsalicylic acid and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when regular analgesic-dose aspirin is given with eprosartan, and maintain hydration. Prefer low-dose aspirin or alternative analgesics where possible.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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