Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Eprosartan
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Eprosartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan is an angiotensin receptor blocker, so combining it with a product that already contains valsartan produces dual ARB therapy without added benefit. This raises the risk of hypotension, hyperkalemia and renal dysfunction, although the thiazide component partly offsets the potassium rise.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Eprosartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Eprosartan belongs to Cardiovascular.
Why it happens
Duplicate blockade of the angiotensin II type 1 receptor causes additive hypotensive, renal and potassium-retaining effects.
What to do
Avoid using two angiotensin receptor blockers together and keep only one. If the combination has been given, check blood pressure, serum potassium and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-olmesartan-hydrochlorothiazide + Eprosartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Eprosartan?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Eprosartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eprosartan is an angiotensin receptor blocker, so combining it with a product that already contains valsartan produces dual ARB therapy without added benefit. This raises the risk of hypotension, hyperkalemia and renal dysfunction, although the thiazide component partly offsets the potassium rise.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Eprosartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two angiotensin receptor blockers together and keep only one. If the combination has been given, check blood pressure, serum potassium and creatinine.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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