Drug interactions
Acetylsalicylic acid + Eptifibatide
Severity: Major
Acetylsalicylic acid and Eptifibatide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eptifibatide is a potent glycoprotein IIb/IIIa inhibitor, and aspirin adds to bleeding risk. The combination is standard in acute coronary syndromes and PCI but requires close bleeding surveillance.
What this interaction means in plain words
Acetylsalicylic acid and Eptifibatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Eptifibatide belongs to Cardiovascular.
Why it happens
Additive platelet inhibition from blockade of the GP IIb/IIIa receptor and irreversible COX-1 inhibition.
What to do
Use under supervised protocols with renally adjusted eptifibatide dosing and low-dose aspirin. Monitor for bleeding, hemoglobin and platelet counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Eptifibatide
Frequently asked questions
Can I take Acetylsalicylic acid with Eptifibatide?
MediHelp rates the interaction as major. Acetylsalicylic acid and Eptifibatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eptifibatide is a potent glycoprotein IIb/IIIa inhibitor, and aspirin adds to bleeding risk. The combination is standard in acute coronary syndromes and PCI but requires close bleeding surveillance.
How serious is the interaction between Acetylsalicylic acid and Eptifibatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use under supervised protocols with renally adjusted eptifibatide dosing and low-dose aspirin. Monitor for bleeding, hemoglobin and platelet counts.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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