Drug interactions
Acetylsalicylic acid + Moexipril
Severity: Moderate
Acetylsalicylic acid and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin at analgesic or anti-inflammatory doses can weaken the antihypertensive action of moexipril and may worsen renal function, especially in dehydrated, elderly or renally impaired patients. Low-dose aspirin has a much smaller effect.
What this interaction means in plain words
Acetylsalicylic acid and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Moexipril belongs to Cardiovascular.
Why it happens
Inhibition of cyclooxygenase reduces vasodilatory renal prostaglandins, opposing ACE inhibitor effects and lowering glomerular filtration.
What to do
Prefer low-dose aspirin when it is needed for cardiovascular protection and avoid regular higher doses. Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Acetylsalicylic acid with Moexipril?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin at analgesic or anti-inflammatory doses can weaken the antihypertensive action of moexipril and may worsen renal function, especially in dehydrated, elderly or renally impaired patients. Low-dose aspirin has a much smaller effect.
How serious is the interaction between Acetylsalicylic acid and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer low-dose aspirin when it is needed for cardiovascular protection and avoid regular higher doses. Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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